Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

NI Strom; ZF Gerring; M Galimberti; D Yu; MW Halvorsen; A Abdellaoui; C Rodriguez-Fontenla; JM Sealock; T Bigdeli; JR Coleman; B Mahjani; JG Thorp; K Bey; CL Burton; JJ Luykx; G Zai; S Alemany; C Andre; KD Askland; J Bäckman; N Banaj; C Barlassina; JB Nissen; OJ Bienvenu; D Black; MH Bloch; S Børte; R Bosch; M Breen; BP Brennan; H Brentani; JD Buxbaum; J Bybjerg-Grauholm; EM Byrne; J Cabana-Dominguez; B Camarena; A Camarena; C Cappi; A Carracedo; M Casas; MC Cavallini; V Ciullo; EH Cook; J Crosby; BA Cullen; EJ De Schipper; R Delorme; S Djurovic; JA Elias; X Estivill; MJ Falkenstein; BT Fundin; L Garner; C Gironda; FS Goes; MA Grados; J Grove; W Guo; J Haavik; K Hagen; K Harrington; A Havdahl; KD Höffler; AG Hounie; D Hucks; C Hultman; M Janecka; E Jenike; EK Karlsson; K Kelley; J Klawohn; JE Krasnow; K Krebs; C Lange; N Lanzagorta; D Levey; K Lindblad-Toh; F Macciardi; B Maher; B Mathes; E McArthur; N McGregor; NC McLaughlin; S Meier; EC Miguel; M Mulhern; PS Nestadt; EL Nurmi; KS O’Connell; L Osiecki; OT Ousdal; T Palviainen; NL Pedersen; F Piras; F Piras; S Potluri; R Rabionet; A Ramirez; S Rauch; A Reichenberg

Journal article

Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

NI Strom, ZF Gerring, M Galimberti, D Yu, MW Halvorsen, A Abdellaoui, C Rodriguez-Fontenla, JM Sealock, T Bigdeli, JR Coleman, B Mahjani, JG Thorp, K Bey, CL Burton, JJ Luykx, G Zai, S Alemany, C Andre, KD Askland, J Bäckman Show all

Nature Genetics | Published : 2025

DOI: 10.1038/s41588-025-02189-z

Abstract

Obsessive–compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the..

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